Arsenal face Napoli in the quarter-finals of the Europa League, Chelsea will take on Slavia Prague and there is an all-Spanish tie between Villarreal and Valencia.
The Gunners overcame Rennes in a superb fightback after trailing from the first leg, while the Blues comfortably hammered Dynamo Kiev in the last-16.
Napoli vs Arsenal
Villarreal vs Valencia
Benfica vs Frankfurt
Slavia Prague vs Chelsea
The first legs will be played on Thursday 11 April with the second legs on 18 April.